Type d'article
Etat
Reliure
Particularités
Livraison gratuite
Pays
Evaluation du vendeur
Edité par Birkhäuser, 1991
ISBN 10 : 0817635661ISBN 13 : 9780817635664
Vendeur : HPB-Red, Dallas, TX, Etats-Unis
Livre
Hardcover. Etat : Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!.
Edité par Taylor & Francis, 1990, 1990
Vendeur : First Choice Books, Coeurd'Alene, ID, Etats-Unis
HB--VG; black glossy cover. contains photos, charts, tables, diagrams; references;
Edité par Birkhäuser, 1996
ISBN 10 : 0817638792ISBN 13 : 9780817638795
Vendeur : HPB-Red, Dallas, TX, Etats-Unis
Livre
hardcover. Etat : Good. Connecting readers with great books since 1972! Used textbooks may not include companion materials such as access codes, etc. May have some wear or writing/highlighting. We ship orders daily and Customer Service is our top priority!.
Edité par Birkhauser, 1991
ISBN 10 : 0817635661ISBN 13 : 9780817635664
Vendeur : K & L KICKIN' BOOKS, Corinth, TX, Etats-Unis
Livre Edition originale
Hardcover. Etat : Very Good. Etat de la jaquette : No Dj. First Edition. B&R-158Ex-college library with usual library features.
Edité par Birkhäuser, 1991
ISBN 10 : 0817635661ISBN 13 : 9780817635664
Vendeur : Midtown Scholar Bookstore, Harrisburg, PA, Etats-Unis
Livre
Hardcover. Etat : Very Good. Very Good - Crisp, clean, unread book with some shelfwear/edgewear, may have a remainder mark - NICE Standard-sized.
Edité par Birkhäuser, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : Lucky's Textbooks, Dallas, TX, Etats-Unis
Livre
Etat : New.
Edité par Birkhäuser, 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : Lucky's Textbooks, Dallas, TX, Etats-Unis
Livre
Etat : New.
Edité par Birkhäuser, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : GreatBookPrices, Columbia, MD, Etats-Unis
Livre
Etat : New.
Edité par Birkhäuser, 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : GreatBookPrices, Columbia, MD, Etats-Unis
Livre
Etat : New.
Edité par Birkhäuser, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : booksXpress, Bayonne, NJ, Etats-Unis
Livre impression à la demande
Soft Cover. Etat : new. This item is printed on demand.
Edité par Birkhäuser, 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : booksXpress, Bayonne, NJ, Etats-Unis
Livre
Soft Cover. Etat : new.
Edité par Birkhäuser, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : Ria Christie Collections, Uxbridge, Royaume-Uni
Livre impression à la demande
Etat : New. PRINT ON DEMAND Book; New; Fast Shipping from the UK. No. book.
Edité par Birkhäuser Boston, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : Buchpark, Trebbin, Allemagne
Livre
Etat : Sehr gut. Zustand: Sehr gut - Gepflegter, sauberer Zustand. | Seiten: 528 | Sprache: Englisch | Produktart: Bücher.
Edité par Birkhauser
ISBN 10 : 0817635661ISBN 13 : 9780817635664
Vendeur : Romtrade Corp., STERLING HEIGHTS, MI, Etats-Unis
Livre
Etat : New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability.
Edité par Birkhäuser Boston Mai 2012, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Allemagne
Livre impression à la demande
Taschenbuch. Etat : Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis. 528 pp. Englisch.
Edité par Birkhauser
ISBN 10 : 0817635661ISBN 13 : 9780817635664
Vendeur : SMASS Sellers, IRVING, TX, Etats-Unis
Livre
Etat : New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. This item may ship from the US or our Overseas warehouse depending on your location and stock availability. We Ship to PO BOX Location also.
Edité par Birkhäuser, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : GreatBookPricesUK, Castle Donington, DERBY, Royaume-Uni
Livre
Etat : New.
Edité par Birkhäuser, 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : GreatBookPricesUK, Castle Donington, DERBY, Royaume-Uni
Livre
Etat : New.
Edité par Birkhäuser, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : Revaluation Books, Exeter, Royaume-Uni
Livre
Paperback. Etat : Brand New. reprint edition. 509 pages. 9.00x6.00x1.25 inches. In Stock.
Edité par Springer-Verlag New York Inc., 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : Kennys Bookshop and Art Galleries Ltd., Galway, GY, Irlande
Livre
Etat : New. Series: Advances in Alzheimer Disease Therapy. Num Pages: 504 pages, 23 black & white illustrations, biography. BIC Classification: MJND. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 26. Weight in Grams: 771. . 2013. Softcover reprint of the original 1st ed. 1991. Paperback. . . . .
Edité par Birkh?user, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : Kennys Bookshop and Art Galleries Ltd., Galway, GY, Irlande
Livre
Etat : New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . .
Edité par Birkhäuser Boston, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : AHA-BUCH GmbH, Einbeck, Allemagne
Livre
Taschenbuch. Etat : Neu. Druck auf Anfrage Neuware - Printed after ordering - Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critical in the mechanism of AD pathogenesis. Detailed characterization of the binding of the apoE isoforms with proteins and peptides relevant to the pathology of the disease may be critical in understanding disease pathogenesis. These critical isoform-specific interactions of apoE may involve interactions with proteins and pep tides in the defining neuropathologic lesions of the disease, the neurofibrillary tangle and senile plaque. Other possible critical isoform-specific interactions include the mechanism of internalization, intracellular trafficking, and subsequent metabolism. In addition, differential post-translational modifications of apoE isoforms may determine differences in metabolism contributing to the pathogenesis of the disease. Oxidation of apoE may confer several isoform-specific, biochemically distinct properties. Since {3A peptide binds apoE in the lipoprotein binding domain of the protein and not in the receptor-binding domain, apoE could target bound {3A4 peptide to neurons via the LRP receptor. Internalization of the apoEI {3A peptide complex into the cell, by the same route as the apoE-containing lipoproteins, would result in incorporation into primary lysosomes and pH dependent dissociation. The demonstration of apoE in the cytoplasm of neurons, with isoform-specific interactions of apoE with the microtubule-binding protein tau demonstrated in vitro, suggest additional, testable hypotheses of disease pathogenesis.
Edité par Birkhäuser Boston, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : moluna, Greven, Allemagne
Livre impression à la demande
Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isoform-specific interactions of apoE therefore become critic.
Edité par Birkhäuser Boston, 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : moluna, Greven, Allemagne
Livre impression à la demande
Etat : New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Springer Book Archives.
Edité par Birkhäuser, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : Kennys Bookstore, Olney, MD, Etats-Unis
Livre
Etat : New. 2012. Softcover reprint of the original 1st ed. 1994. paperback. . . . . . Books ship from the US and Ireland.
Edité par Springer-Verlag New York Inc., 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : Kennys Bookstore, Olney, MD, Etats-Unis
Livre
Etat : New. Series: Advances in Alzheimer Disease Therapy. Num Pages: 504 pages, 23 black & white illustrations, biography. BIC Classification: MJND. Category: (P) Professional & Vocational. Dimension: 235 x 155 x 26. Weight in Grams: 771. . 2013. Softcover reprint of the original 1st ed. 1991. Paperback. . . . . Books ship from the US and Ireland.
Edité par Birkhauser 2012-05, 2012
ISBN 10 : 1461581516ISBN 13 : 9781461581512
Vendeur : Chiron Media, Wallingford, Royaume-Uni
Livre
PF. Etat : New.
Edité par Birkhäuser, 1996
ISBN 10 : 0817638792ISBN 13 : 9780817638795
Vendeur : Romtrade Corp., STERLING HEIGHTS, MI, Etats-Unis
Livre
Etat : New. Brand New Original US Edition.We Ship to PO BOX Address also. EXPEDITED shipping option also available for faster delivery.This item may ship from the US or other locations in India depending on your location and availability.
Edité par Birkhäuser, 1996
ISBN 10 : 0817638792ISBN 13 : 9780817638795
Vendeur : SMASS Sellers, IRVING, TX, Etats-Unis
Livre
Etat : New. Brand New Original US Edition. Customer service! Satisfaction Guaranteed. This item may ship from the US or our Overseas warehouse depending on your location and stock availability. We Ship to PO BOX Location also.
Edité par Birkhäuser, 2013
ISBN 10 : 1489967400ISBN 13 : 9781489967404
Vendeur : GreatBookPricesUK, Castle Donington, DERBY, Royaume-Uni
Livre
Etat : As New. Unread book in perfect condition.